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Regulation of SLC7A11 does not alter cell proliferation, but its overexpression increases the growth of anchorage-independent cells ( A number of studies have reported that the system xc - is related to many properties of glioma cells

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Scienceasia49 (2023): 177-183

The TARDBP familial CTRL fibroblasts, unlike unrelated CTRLs cells, rely more on glycolysis than on oxidative phosphorylation for ATP production, despite the loss of efficiency, due to impaired electron transfer and mitochondrial ATP production that slow down the Krebs cycle