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Because it is essentially water without sufficient solute, direct intravenous administration can cause red blood cell lysis (hemolysis) due to its hypotonic nature

There is no published compatibility or stability data for the two peptides combined in a single solution, so keeping them separate is the conservative handling choice

Medically reviewed by Shari Forschen, NP, MA This article was medically reviewed by Shari Forschen, NP, MA

Biochemically, the cobalt center can take part in both two-electron and one-electron reductive processes to access the "reduced" (B 12r , +2 oxidation state) and "super-reduced" (B 12s , +1 oxidation state) forms

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Reported adverse effects in small human studies include headache, dizziness, and transient blood pressure changes