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reported that cells highly dependent on mitochondrial respiration exhibit significantly greater sensitivity to CIs than those primarily relying on glycolysis ( Lipoylation is a conserved post-translational modification that regulates protein function by covalently attaching lipoic acid to lysine residues ( The primary regulators of protein lipoylation are lipoyltransferase 1/2 (LIPT1/2) and lipoic acid synthase (LIAS)

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FIGURE 1 Glutathione S -transferases are important enzymes that catalyze the conjugation reaction between GSH and chemically reactive drug metabolites

Pyruvate is subsequently converted into acetyl-CoA in the mitochondrial matrix, which enters the TCA cycle as citrate after condensation with oxaloacetate

While some people take probiotics hoping to restore their hair, Kalan said current evidence remains limited, and these products are only likely to help if an underlying digestive condition is affecting nutrient absorption