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These differing observations are integrated within the DNA damage-cGAS-STING axis and collectively underscore the therapeutic complexity of targeting this pathway [76, 77]

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As proof of principle, we have developed small molecules that target PTPs, termed redox-based probes (RBPs, Fig

We help determine whether the project calls for a biologically relevant S-conjugate, a terminally derivatized GSH analogue, or a protected intermediate that preserves one functional group while another is modified

N The protein expression of HSP90 and GPX4 was examined by WB in LLC cells-derived subcutaneous xenografts tumor

10.1016/j.jbc.2023.105457 98 PrudovaA.BaumanZ.BraunA.VitvitskyV.LuS