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Besides these the antioxidant and anti-inflammatory properties exhibited by silymarin also reduces the risk of diabetic complications like neuropathy

10.1016/j.bbrc.2019.02.077 70 TangC.LivingstonM

Antioxidant capacity is connected to the capability to neutralize superoxide and hydroxyl radicals, which helps prevent free radical that induced retinal pigment epithelium death [288]

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These drugs induce apoptosis inhibition by forming a complex with the intracellular immunophilin FKBP12 thus inhibiting the phosphorylation of the mTOR targets, S6K1 and 4E-BP1, as a result, the activation of cyclin-dependent kinases (CDK) is prevented, specifically, the expression of cyclin D1 is found to be decreased meanwhile p27 increases and consequently, cells arrested at G1/S phase die either by autophagy or apoptosis (197, 198)