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4 Conclusions and challenges Targeted pathways are crucial for preventing chronic inflammatory diseases, reducing patient adverse reactions, and improving cure rates

The correspondent threshold oxaliplatin concentration in ultrafiltrate plasma platinum concentrations was determined as 0.15 g/mL (Cattel et al., 2003)

Trust the process and stay consistent for 16-24 weeks minimum

According to the NCCN ( Figure 1 Histologic confirmation of disease: This includes a confirmed diagnosis of grade 1, endometrioid adenocarcinoma limited to the endometrium (Stage IA), or AEH, based on endometrial ( Absence of myometrial invasion or metastasis: Imaging studies (MRI preferred) should confirm that the disease is confined to the endometrium, with no evidence of myometrial invasion, cervical involvement, or distant metastasis ( Patients should have no contraindications to hormonal therapy: This includes evaluating the patients medical history for contraindications to progestins or other hormonal treatments ( Strong patient commitment to follow-up: Patients need to be highly compliant with close follow-up, as fertility-preserving treatment requires ongoing monitoring of the disease ( The cornerstone of fertility-preserving treatment in both AEH and early-stage EC is hormonal therapy

Upon activation, S6K1 phosphorylates several substrates, including the ribosomal protein S6 (rpS6), which enhances the translation of mRNAs with oligopyrimidine tracts in their 5-UTRs 14