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Medical Therapy First-Tier Drugs: VMAT2 Inhibitors (Table 3) Mechanism VMAT2 is a key vesicular protein that traverses the membrane and is involved in recycling dopamine, norepinephrine, and serotonin after their reuptake into the neuron from the synaptic cleft

Its primary job is to tackle the threat of free radicals

Expansion of DUB functionality generated by alternative isoforms USP35, a case study

Excess iron can drive oxidative stress , essentially creating internal "rust", which damages cells, contributes to inflammation, and ironically impairs detoxification

459,460,461,462 ROS help transport the FOXO transcription factor into the nucleus through phosphorylation by JNK or MST1

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