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Deng et al (105) demonstrated that melatonin promotes p62 degradation by suppressing TFAM acetylation through SIRT3 activation, thereby enhancing mitophagy flux

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Cancer-associated mutation and beyond: the emerging biology of isocitrate dehydrogenases in human disease

As a consequence, proteins that should be modified by vitamin K are not, including proteins essential to blood clotting, and are thus not functional