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doi:10.1111/j.1572-0241.2005.00248.x 10Hanauer SB, Sandborn WJ, Dallaire C, et al

Half of the dose (with some excess) was given in a canister at visit 4 after randomization

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39 Similarly, treatment with once-weekly retatrutide 12 mg for 48 weeks resulted in a 24.2% mean weight reduction compared with 2.1% for placebo, with 83% of participants achieving 15% weight loss