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Dopamine is heavily involved in the brain's reward center, motivation, and executive function, while norepinephrine helps sustain focus and alertness during periods of stress

AD pathology is now seen as a complex network where insulin signaling issues, A accumulation, and tau hyperphosphorylation interact and worsen each other within the A/T/N framework (Amyloid/Tau/Neurodegeneration) (64)

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In both sexes, the liver has the highest GST activity of both the organs tested