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Myelin sheaths are completely lost, while oligodendrocyte cell bodies may be partly preserved within active lesion areas

When the CAR T cells are infused into the circulation, the modified receptors bind to a specific antigen on the target cells (e.g., cancerous cells in B cell malignancies) and destroy them

69 A second area is the endoplasmic reticulum (ER) stress response, which is induced by the accumulation of unfolded or misfolded proteins

Due to protein denaturation, the inner lens swells and turns opaque as a result of the breaking down of the outer lens capsule

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It may reflect an underlying insulin resistance and can mean the patient is potentially at risk for having diabetes