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Iwamoto, S., Mihara, K., Downing, J

Estrogen, angiogenesis, immunity and cell metabolism: solving the puzzle

A recent programme examining 4006 proteins from serum, CSF and brain tissue 114 , identified a signature of proteins more strongly associated with PD (with AUC ranging from 0.66 for serum, to 0.75 for brain tissue), including proteins from cytokine receptor interaction and complement pathways

The best candidates can then be combined with gene HI fusions that encode pathogenic epitopes of interest

Its an exciting time, but it also brings a flood of complex questions

Restoring DLX-mediated GABAergic neuron differentiation or enhancing GABA signaling (e.g., via GABAA receptor agonists) could potentially rescue circuit imbalances in DLX-related ASD subtypes