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This characteristic sets it apart from many epitope tags that are simply short peptides

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Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells

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While preconditioned, short, or moderate hypoxic exposures can stimulate repair through angiogenesis, enhanced stemness, and metabolic adaptation, sustained or severe hypoxia may instead promote fibrosis, cellular exhaustion, or maladaptive remodeling [97]