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The purine path to chemotherapy

Pegg, A

Kumar B, et al

Schuurman H-J, Van Loveren H, Rozing J, & Vos JG (1992) Chemicals trophic for the thymus: risk for immunodeficiency and autoimmunity

The S-plots (Fig

On the other hand, the activity of methionine catabolic enzymes (e.g., methionine oxidase) is elevated in exhausted T cells, further accelerating methionine consumption