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In some embodiments, the composition comprises about 0.01 milligrams (mg) to about 10 mg of CBD, about 0.5 mg to about 50 mg niacinamide, about 0.1 mg and 100 mg L-ergothioneine per milliliter of composition, and a mitophagy stimulant, wherein the mitophagy stimulant is urolithin A

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Camell, C

10.1146/annurev-biophys-101920-082204 [DOI] [PMC free article] [PubMed] [Google Scholar] 10

Current approaches are largely restricted to experimental settings, while available inhibitors, such as non-specific antioxidants or iron chelators, exhibit limited specificity and raise safety concerns related to off-target effects and disruption of systemic iron homeostasis