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However, pegylated uricases are highly immunogenic resulting in the formation of anti-drug antibodies (ADAs) in ~90% of patients 2,7 , correlating with the loss of therapeutic benefit and increased infusion reactions 2

PSR-1 CTD modulates PSR-1 condensate properties and PSR-1 function Proteins that form phase separated condensates through multivalent interactions usually fall into two categories: those featuring modular domains and those characterized by intrinsically disordered regions (IDRs) 64

NAC is used by the liver and the lymphocytes to detoxify chemicals and other poisons

Binding of ubiquitinated proteins to USP14 causes 20S proteasome gate opening, thereby linking proteasomal deubiquitination to protein degradation (Peth et al., 2009)

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Although miR-214 alone had little effect on the cell viability of AML12 cells (Fig