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This approach would move Gut-on-a-Chip studies beyond cataloging molecular differences and toward mechanism-based prediction of patient-specific intestinal first-pass metabolism

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One is the permeability barrier that is regulated predominantly by tight junctions (Turner, Reference Turner2009)

As a specialized membrane structure, gap junctions are low-resistance channels that connect adjacent cells, transmit electrical impulses in an excited state, and transport small molecules involved in metabolism and growth in a normal state (49, 50)