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Crucially, the hematogenous route has gained increasing recognition as a non-canonical pathway for uterine seeding

doi: 10.4330/wjc.v6.i6.462 38 BardaweelSKGulMAlzweiriMIshaqatAALSalamatHABashatwahRM

269 When mechanical stress is applied to the ligament, integrins cluster and recruit focal adhesion proteins, activating intracellular signaling pathways such as the MAPK/ERK and RhoA/ROCK pathways