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Finally, through multicenter, large-sample clinical cohort studies combined with statistical methods, derive and validate clinically meaningful cutoff values to enable precise patient stratification and individualized treatment

A significant increase in midazolam exposure (respectively from 3.02-fold to 26.41-fold for AUC and from 1.15-fold to 4.27-fold for C max ) in healthy volunteers concomitantly treated with ritonavir alone or ritonavir-boosted PIs has been reported, caused by strong inhibition of CYP3A4 [92,93,94,95]

doi: 10.3389/fendo.2023.1070264 161 JinHZhaoKLiJXuZLiaoSSunS

The primer sequences used for conventional PCR and qRT-PCR analysis are listed in Supplementary Table 1

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Safety profile and risk assessment FTPP carries more safety concerns than most peptides in the research space