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Given these potential mechanisms, this study was designed to test the hypothesis that DIO mice restored to the weight and adiposity of LD controls through NNMTi treatment and LD switch 13 have a similar microbiome profile to mice continuously maintained on LD

Tesamorelin is FDA-approved under the brand name Egrifta for the reduction of excess abdominal fat in HIV-infected adults with lipodystrophy

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Part A was a double-blind, placebo-controlled, sequential, single-ascending-dose safety study of ImmTOR, and Part B was an open-label, sequential, single-ascending dose study of SEL-212, a combination product candidate consisting of a fixed dose of pegadricase combined with ascending doses of ImmTOR, in patients with hyperuricemia with or without a clinical diagnosis of gout (Fig