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The downstream pathway of Nrf2, on the other hand, involves inhibitory effects on oxidative stress, inflammation and apoptosis, including but not limited to several important protein molecules, such as HO-1, SOD, MDA, TNF-, ILs, the caspase family of proteins, Bcl-2 and Bax

The uncoupling of endothelial nitric oxide synthase (eNOS), oxidative stress mechanism is involved in uremia, a condition when the kidney does not work properly and waste products instead of urine are excreted into the bloodstream (Himmelfarb et al

I 2 = 0.0%, p = 0.895), and SHBG (SMD: 19.17

33,34 Other nutritional medical approaches to hypertension management include increased consumption of lycopene, mainly from tomato and watermelon, 35 cocoa, 36 and garlic, discussed here

doi: 10.1016/j.jacc.2021.03.293 67

The docking simulations were carried out using the Lamarckian Genetic Algorithm with the default docking parameter