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Intervention strategies against IAV via targeting PCD pathways Although multiple classes of antiviral agents-such as the neuraminidase inhibitor oseltamivir and the RNA polymerase inhibitor baloxavir-have been approved for clinical management of IAV infection, their therapeutic efficacy remains constrained by several factors, including the rapid emergence of drug-resistant viral strains, a narrow antiviral spectrum, and suboptimal outcomes in severe or late-stage infections (177, 187)

A pharmaceutical composition according to the present invention may be especially beneficial in conferring stability to the activatable antibody construct where the pi of the at least two masking moieties of the at least two binding domains differ

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For example, if melanoma spreads to the lung, the cancer cells in the lung are actually melanoma cells

10.3390/nu14122413 15

10.3390/nu11020258 174