glutathione and glutamate cysteine liaase Frontiers Covalent Targeting of Glutamate Cysteine

Il s'agit d'une technologie liposomale

Glutathione (GSH) Key Research Facts Chemical identity: Tripeptide gamma-glutamyl-cysteinyl-glycine (Glu-Cys-Gly) Molecular weight: 307.32 Da (reduced form, GSH) Cellular concentration: 110 mM in cytosol

Dai E, Zhang W, Cong D, Kang R, Wang J, Tang D

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On the basis of these observations, and as suggested by our model in which HPV-16 E7 occupies the space between Cys 47 and Cys 101 of GSTP1 and prevents both intramolecular and intermolecular disulfide formation, we propose that HPV-16 E7 binding might protect GSTP1 against inactivation via oxidative attacks at Cys 47 and/or Cys 101