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Adeva-Andany M, Lopez-Ojen M, Funcasta-Calderon R, Ameneiros-Rodriguez E, Donapetry-Garcia C, Vila-Altesor M, Rodriguez-Seijas J

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Patients with Lebers hereditary optic neuropathy should not receive B12 due to the risk of optic nerve damage

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To determine CI activity, MAS plus alamethicin (2.5 g ml 1 ) and cytochrome c (10 g ml 1 ) were added to the mitochondria followed by 5 mM pyruvate + 5 mM malate + 1 mM NADH at port A, 2 M rotenone + 4 M antimycin A at port B, 0.5 mM TMPD + 1 mM ascorbic acid at port C and 50 mM azide at port D

MBOAT1 and MBOAT2, newly identified negative regulators of ferroptosis, remodel membrane phospholipids to reduce their susceptibility to oxidation