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Furthermore, compared to normal controls, individuals with eating disorders have also shown decreased GSH synthesis, and a therapeutic dose of APAP could potentially be an overdose, complicating the livers ability to reduce the toxic metabolite NAPQI in the case of APAP-induced hepatotoxicity [20]

Tumor volumes were calculated by using the formula V = ( D d 2 )/2 mm 3 , where D is the largest diameter and d is the shortest diameter

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We then computed the QM-based descriptors (with both DFT and PM7 methods) on the experimental conformation, and we compared the results with those derived from the corresponding QM-optimized geometries (Supporting_TableS 4a, Supporting_TableS 4b)

It has been demonstrated that the missense variant NQO1, found in 4-20% of the human population, results in no detectable NQO1 activity due to rapid degradation of the NQO1 P187S protein