It is rare in plant-based products, so people with a vegan diet can often suffer from vitamin B12 deficiency and related symptoms
Lee AC, Fenster BE, Ito H, Takeda K, Bae NS, Hirai T, Yu ZX, Ferrans VJ, Howard BH, Finkel T (1999) Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
In the most comprehensive pediatric meta-analysis, Contopoulos-Ioannidis et al., ( Age-specific extended-interval protocols account for developmental pharmacokinetic variability, particularly the maturational changes in GFR and volume of distribution that influence aminoglycoside clearance across gestational and postnatal age
-Aminobutyric acid-A (GABA-A), amyloid beta (A), peroxisome proliferator-activated, receptor-gamma coactivator-1 (PGC-1), PTEN-induced putative kinase 1 (PINK1), reactive oxygen species (ROS), sirtuin 1 (SIRT1), nuclear factor kappa-light-chain-enhancer of activated cells (NF-kB), forkhead box O (FOXO), diabetic autonomic neuropathy, tumor necrosis factor (TNF), interleukin-1 (IL-1), interleukin-6 (IL-6), advanced glycation end products (AGE), protein kinase C (PKC), N-methyl-D-aspartate (NMDA), bloodbrain barrier (BBB), insulin receptor (IR), phosphorylated Tau, acetylcholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), malonaldehyde (MDA), low-density lipoproteins-cholesterol (LDL-C), hemoglobin A1c (HbAlc), and glycogen synthase kinase-3 beta (GSK3B)
Vitamin B12 deficiency can lead to severe health consequences, including megaloblastic anemia and neurological disorders, as noted by medical professionals
Among these, 38 are known secreted proteins (70.4%) and 37 were previously reported as itaconated (68.5%), mirroring the specificity we observed in Raw264.7 cells (Supplementary Fig
