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Glutathione S -transferase catalyzes the isomerization of ( R )-2-hydroxymenthofuran to mintlactones

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The use of ROS inhibitors effectively counteracted the enhancement of A-induced IL-1 release by iron and prevented the activation of NF-B and mitogen-activated protein kinase (MAPK) in microglia [93, 94], highlighting the critical role of oxidative stress in microglial inflammation

Lee CL, Cremona M, Farrelly A, Workman JA, Kennedy S, Aslam R, et al

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It is determined that oxidation is an initial stage in the sequence of steps that lead to cataracts