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doi:10.1371/journal.pone.0154345

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Review Article OPEN ACCESS Dongjie Wu 1,# , Qingjuan Wu 1 , Yanxuan Wu 2 , Ziwei Guo 1 , Li Wang 1 , Yi Wang 1,3 , Qian Zeng 4 , Liang Shi 2 , Bin Shi 2 , Gongchang Yu 2,* and Wenliang Lv 1,* Author information Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), the most common chronic liver disorder worldwide, results from multidimensional network dysregulation involving lipid metabolism imbalance, insulin resistance, oxidative stress, chronic inflammation, and gut-liver axis disruption