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After one-third of the study participants have been enrolled and completed follow-up, the DSMBs will review the data and make recommendations concerning continuation, modification or termination of the study due to unexpectedly large beneficial effects or serious side effects and can suggest extension of the trial should the primary outcomes occur less often than anticipated

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Future integration of hydrogel-based carriers may further prolong local tissue exposure and enhance biologic residence time

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Thus, RBC and likely platelets in biological fluids may sequester a portion of the antibody pool away from their therapeutic targets (82)