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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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Mechanistically, this makes sense

May be repeated once or twice weekly

Mechanistically, it acts systemically: it sequesters G-actin, promotes endothelial cell migration in scratch-wound assays, and has shown progenitor-cell mobilization signals in preclinical cardiac models

However, because sermorelin can also increase your appetite, Kota notes it may not be appropriate as a stand-alone treatment for someone who is already struggling with cravings or binge eating