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Additionally, healthy cells are susceptible to cytotoxic agent-induced pyroptosis due to the extensive expression of gasdermins in normal tissues [224]

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Consequently, this leads to increased vasoconstriction, inflammation, and remodeling of resistant arteries

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Cells were then cultured for additional 72 hours and either left untreated or triggered for 2 minutes with 10 M of substance P with or without prior treatment with the desired inhibitors