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Marcel Arnold: Honoraria for lecturs: Astra Zeneca, Bayer, Novartis, Sanofi, Scientific advisory boards: Amgen, BMS/Pfizer, Novo Nordisk, Daiichi Sankyo, Medtronic, Novartis, Grants Swiss National Science Foundation Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.10 - ESUS/CRYPTOGENIC STROKE P326 - ESOC25-2305 A MACHINE LEARNING BASED APPROACH TO IDENTIFY ESUS ETIOLOGIES Adriano Bonura 1 , Claudia Meza 1 , Jesus Juega 1 , Marian Muchada 1 , Alvaro Garcia-Tornel 1 , Federica Rizzo 1 , Renato Simonetti 1 , Marta Olive 1 , Marc Rodrigo 1 , Noelia Rodriguez-Villatoro 1 , David Rodriguez Luna 1 , Marta Rubiera 1 , Carlos Molina 1 , Jorge Pagola 1 Vall dHebron, Stroke Unit, Barcelona, Spain Background and Aims: Embolic Stroke of Undetermined Source (ESUS) accounts for about one-quarter of all ischemic strokes and poses a notable challenge in modern vascular neurology due to its high recurrence rate and diverse underlying mechanisms