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Besides acting as an intermediate in an active DNA demethylation pathway, 5hmC may also serve as a stable neuronal epigenetic mark in its own right [43]

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Identification, characterization, and expression profiling of rice MADS-box transcription factor genes associated with fluroxypyr-meptyl and oxyfluorfen metabolism

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If the percentage of mutant mtDNA continues to increase, this will consequently result in a gradual and continuous decrease in energy production until a bioenergetic threshold is reached (Wallace, 1999)