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The detailed study of the expression of receptors on immune cells together with that of ligands on MB cells as well as other components of the TME could suggest the main molecules to be targeted by immunotherapy

Timing Optional Monitoring guidance is pathway-based, with copper and liver context added for repeated systemic exposure discussions

Functional receptor binding studies with cubilin should be conducted in the future, using purified cubilin domains and IF-B12 complexes in FPLC-based assays or mass spectrometry-coupled interaction analyses to quantify binding kinetics and stoichiometry

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Role of gut microbiota in cardiovascular diseases

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