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Understanding these effects is crucial for proper patient management and therapy optimization

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AMPK also promotes, albeit indirectly, PGC 1 deacetylation and activation, which is mediated by the NAD-dependent protein deacetylase sirtuin-1 (SIRT1) whose activation is a direct consequence of the increase in NAD + :NADH ratio (Canto and Auwerx, 2009)

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