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Interestingly, while Epothilone B was identified as a P-glycoprotein substrate, the glutathione-epothilone conjugate was not, suggesting potential differences in cellular retention

E9, June 30, 2002

Here, we employed comparative global metabolomics to demonstrate that metabolism of the antioxidant glutathione (GSH) is inextricably linked to redox-active processes that facilitate melanin production, and that genetic perturbations in GSH biosynthesis affect fungal growth and virulence in a murine model of cryptococcosis

Using a similar strategy, Wangs lab has developed a sulfonyl azidedansyl derivative, whose electrical and fluorescent properties are due to the different electronegativity of the azide and amine groups

10.1065/espr2006.10.352 141 SeifbarghiS.BorhanM

This section will take a closer look at the impact of low, moderate, and high BAC levels