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Mitochondria, also surrounded by membranes with an electrical charge of approximately 170 millivolts

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For example, while ISA inhibits the cytochrome c oxidase in the presence of their substrates (ascorbate/N, N, N, N- tetramethyl- p -phenylenediamine dihydrochloride), one ISA-serotonin conjugate enhances the mitochondrial complex IV activity and overall respiration function of mitochondria (Neganova et al., 2024)

doi:10.1016/j.jtemb.2022.127048 Xiao H, Parkin KL

Variation in redox state, as represented by the intracellular GSH:GSSG ratio, can have profound clinical implications, enhancing cell signalling and even cell death