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This pattern suggests continuous daily Dihexa administration beyond 4-6 weeks without rest periods would likely trigger protective receptor downregulation, reducing compound effectiveness over time

[DOI] [PubMed] [Google Scholar] 136.Tokunaga Y., Sakakibara Y., Kamada Y., Watanabe K., Sugimoto Y

Biol Psychiatry (2010) 67:10106.10.1016/j.biopsych.2009.12.004 256 McCullumsmithREKristiansenLVBeneytoMScarrEDeanBMeador-WoodruffJH

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It has also been shown in research to activate the CREB/PGC-1-alpha pathway, which plays a role in suppressing neuroinflammation by reducing pro-inflammatory cytokines and promoting anti-inflammatory mediators