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Sleep is often disrupted by pain, and many patients have other sleep disorders, such as restless legs syndrome and sleep apnea

Bodybuilding, weight-loss, and sexual-enhancement products are the most common types of supplements that the FDA has found to often contain undeclared drugs, and some of the drugs identified included phosphodiesterase inhibitors (for erectile dysfunction), diuretics, and sibutramine (for weight loss), among others

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Direct receptor-mediated effects This is where things get scientifically fascinating