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Suzuki K, Doki K, Homma M, Tamaki H, Hori S, Ohtani H, Sawada Y, Kohda Y (2009) Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy

Jun 2024;42(6):1215-1223.doi:10.55563/clinexprheumatol/3l0ihz

In the foundational 1996 dose-ranging study in healthy elderly subjects, oral MK-677 increased 24-hour GH concentrations in a dose-dependent manner roughly doubling mean GH at the 25 mg dose and the researchers attributed this to an enhancement of pre-existing pulsatile GH secretion : pulse height and interpulse nadir concentrations rose, while the number of pulses did not change significantly

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Research suggests that baicalein has the potential to alleviate ovalbumin (OVA)-induced allergic airway inflammation and mast cell-mediated anaphylaxis by modulating the Th1/Th2 balance and inhibiting histamine release (Zhang et al., 2020a) findings suggest that this approach could serve as an effective delivery route for the treatment of related diseases