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Simeons protocol included HCG injections and a strict diet

Patients should be informed of the pros and cons of oral versus parenteral therapy, and regardless of the form of treatment, those with pernicious anemia or malabsorption should be reminded of the need for lifelong replacement

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According to Gladtke (1966), the elimination half-life of sodium thiosulfate is about 40 min (children aged 4 months to 14 years)

However, given the results reported in previous studies (2,25,31-33) that used moderate/high doses of vitamin B12, it should be possible to demonstrate the non-inferiority of the oral treatment with this power level