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To account for potential outliers, an additional eight subjects (2 per arm) results in a total sample size of N = 128

Most catalases are haemin-containing enzymes (i.e., their active sites consist of a ferric Fe 3+ ion complexed within a planar cyclic tetradentate porphyrin ligand [Milgrom, 1997]) made up of tetrameric protein subunits (see Figure 2)

Further studies have revealed two compensatory downstream molecular pathways within the Hippo pathway: the Yes-associated protein (YAP) - S-phase kinase-associated protein 2 (SKP2) pathway and the WW domain-containing transcription regulator 1 (TAZ) - ERM protein 1 (EMP1) - NADPH oxidase 4 (NOX4) pathway

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