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After incubation with TruStain fcX -mouse CD16/32 blocking antibody (BioLegend), staining of different surface markers (see Table 1) was performed for 20 min at 4C followed by a washing step with PBS/1% FCS

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Visualization of biodistribution and deep tumor penetration Cy5-labeled paclitaxome (70 mg PTX kg 1 ) or Cy5/PTX/LipoSM (40 mg PTX kg 1 ) were intravenously injected into orthotopic 4T1-Luc2 or KPC-Luc tumors mice ( n = 3 mice/group, ~400 mg)

10.1038/s41580-019-0123-5 335 ZhuangH.WuF.WeiW.DangY.YangB.MaX.et al

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Astrocytes with a neuroprotective role produce ciliary neurotrophic factor (CNTF) and BDNF increasing neuronal survival (Lee et al., 1998