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Bioessays 35 , 965973 (2013)

Gaike AH, et al

In this context, the crosstalk between cancer cells, LECs and immune cells and how this communication can shape the immune landscape in the TME is gaining increased interest in recent years

However, excessive activation of autophagy may result in adverse effects, as the process also contributes to follicular atresia and granulosa cells death

Under normal conditions in senescent cells, FOXO4 interacts with p53 and retains it in the nucleus, preventing p53 from translocating to mitochondria and executing its intrinsic pro-apoptotic programme