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Park SB, Kwok JB, Asher R, Lee CK, Beale P, Selle F, Friedlander M (2017) Clinical and genetic predictors of paclitaxel neurotoxicity based on patient- versus clinicianreported incidence and severity of neurotoxicity in the ICON7 trial

Once inside the cell, metformins positive charge leads to its sequestration within the negatively charged mitochondrial matrix, where it can reach concentrations up to 1,000-fold higher than in the extracellular space ( The cardioprotective effects of metformin are both dose-dependent and tissue-specific (Table 2)

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Curr Cancer Drug Targ 3:219236 Chen ML et al (2016) Resveratrol attenuates trimethylamine- N -oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota

In line with this idea, the European Year of Cultural Heritage has positioned cultural heritage as a resource for the future, putting local communities at the centre, promoting accessibility and supporting public development (COM, 2018)