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Temporary Bloating Though rare, some individuals experience slight bloating or digestive discomfort, which may be related to its immune-modulating and anti-inflammatory properties

A randomized, open-label, dose-ranging, Phase 2 study (NCT04238481) in adults undergoing laparoscopic colorectal surgery demonstrated that a single administration of pudexacianinium provides ureteral visualization for the full duration of minimally invasive, laparoscopic colorectal procedures at doses of 1 mg and 3 mg [12]

Sourcing is the more immediate problem

Other B Complex Side Effects and When to See a Doctor Outside of stool changes, you may experience other side effects when taking B complex supplements, including: Diarrhea Facial redness Extreme tiredness Headache Nausea Upset stomach Bright yellow pee However, unless these are persistent or interfere with daily life, you may not need to see a healthcare professional if you experience these effects

With those caveats in mind, here's what the published data shows at each stage

The Role of Vascular Endothelial Growth Factor in the Hypoxic and Immunosuppressive Tumor Microenvironment: Perspectives for Therapeutic Implications