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As such, an effective treatment would be expected to augment striatal synaptic connectivity, protect SN neurons from underlying death inducers, and ideally stimulate the replacement of lost SN neurons from preexisting pools of neural stem cells

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Interaction Uncertainty : Potential interactions with medications or underlying conditions remain unknown due to the absence of controlled human studies

The time spent by the mouse in exploring the novel object, in comparison to the familiar object, and taking into account general exploratory/locomotor activity, is taken as a measure of learning and memory ('cognition')

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