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You may need a gastrectomy if you experience: Diagnosed stomach (gastric) cancer requiring surgical treatment Large or multiple gastrointestinal stromal tumors (GISTs) Recurrent or complicated peptic ulcers not responding to medical management Perforated stomach ulcers with severe complications Gastroparesis (delayed stomach emptying) that severely affects quality of life Corrosive injury to the stomach from accidental chemical ingestion Trauma to the stomach requiring surgical intervention Morbid obesity requiring surgical treatment (sleeve gastrectomy) Polyps with high-risk features that cannot be removed endoscopically Gastric outlet obstruction that is not manageable with less invasive techniques Severe bleeding from the stomach, not controllable with endoscopic methods Family history of hereditary diffuse gastric cancer with genetic confirmation Our approach to gastrectomy combines precision with personalized care

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For the purpose of this review, separate MMRM analyses were performed for the three phase 3a SCALE trials [38] and, in general, the treatment effects estimated using the MMRM analysis method were larger than those estimated using LOCF (Table 2)

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