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The dual-mechanism approach may also offer specific advantages for particular patient subgroups, including those with type 2 diabetes and obesity where cardiometabolic improvements beyond weight loss are clinically important

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Neurotrophins: transcription and translation

The rationale is that glucagon also increases energy expenditure and promotes hepatic fat mobilization, so a molecule that combines glucagons metabolic-rate effect with GLP-1/GIPs appetite-and-glucose control can, in principle, drive weight loss from both sides of the energy-balance equation at once

Bull Exp Biol Med 2012;153:2558

These separate, but related mechanisms of action of an amylin-analog and a GLP-1 receptor agonist appear to have an additive effect on appetite reduction