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Description

TMAO is mostly excreted in the urine (Al-Waiz et al., 1987

Ganne-Carrie N, Medini A, Coderc E, Seror O, Christidis C, Grimbert S, Trinchet JC, Beaugrand M

Toxicology 457 , 152808 (2021)

SMAD2 mediates the signal of TGFB and regulates certain cellular-damaging processes, including converting normal quiescent valve interstitial cells (qVICs) of the mitral valve into disease-derived activated myofibroblasts (aVICs)